| 1. Jornada | 24.07.2021 | Sparta Praga | - | Sigma Olomouc | 3:2 |  |
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| 2. Jornada | 31.07.2021 | Slovan Liberec | - | Sparta Praga | 0:5 | ||||
| 3. Jornada | 07.08.2021 | Sparta Praga | - | MFK Karviná | 2:0 | ||||
| 4. Jornada | 14.08.2021 | Bohemians Praha 1905 | - | Sparta Praga | 1:1 | ||||
| 5. Jornada | 21.08.2021 | Sparta Praga | - | FC Hradec Králové | 4:0 | ||||
| 6. Jornada | 28.08.2021 | Sparta Praga | - | Dynamo České Budějovice | 1:0 | ||||
| 7. Jornada | 11.09.2021 | Viktoria Plzeň | - | Sparta Praga | 3:2 | |
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| 8. Jornada | 19.09.2021 | Sparta Praga | - | FK Jablonec | 1:1 | |
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| 9. Jornada | 25.09.2021 | FC Fastav Zlín | - | Sparta Praga | 2:5 | ||||
| 12. Jornada | 24.10.2021 | Sparta Praga | - | FK Mladá Boleslav | 1:0 | ||||
| 15. Jornada | 21.11.2021 | 1. FC Slovácko | - | Sparta Praga | 4:0 | ||||
| 16. Jornada | 28.11.2021 | Sparta Praga | - | Slovan Liberec | 2:1 | |
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| 17. Jornada | 04.12.2021 | MFK Karviná | - | Sparta Praga | 1:2 |
Suecia