| 1. Jornada | 24.07.2021 | Sparta Praga | - | Sigma Olomouc | 3:2 |  |
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| 2. Jornada | 31.07.2021 | Sigma Olomouc | - | FK Pardubice | 3:2 | ||||
| 4. Jornada | 14.08.2021 | Sigma Olomouc | - | Dynamo České Budějovice | 3:3 | ||||
| 5. Jornada | 21.08.2021 | FC Fastav Zlín | - | Sigma Olomouc | 1:4 |  |
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| 6. Jornada | 29.08.2021 | Sigma Olomouc | - | FK Jablonec | 4:0 | ||||
| 7. Jornada | 12.09.2021 | FK Mladá Boleslav | - | Sigma Olomouc | 3:3 | |
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| 24. Jornada | 05.03.2022 | Sigma Olomouc | - | Bohemians Praha 1905 | 0:0 | ||||
| 25. Jornada | 13.03.2022 | MFK Karviná | - | Sigma Olomouc | 1:2 | ||||
| 26. Jornada | 20.03.2022 | Sigma Olomouc | - | Slovan Liberec | 1:0 | ||||
| 27. Jornada | 02.04.2022 | 1. FC Slovácko | - | Sigma Olomouc | 1:0 | ||||
| 29. Jornada | 17.04.2022 | FC Hradec Králové | - | Sigma Olomouc | 3:0 |
República Checa