| 1. Jornada | 09.01.2022 | Santos Laguna [] | - | CF Monterrey [] | 2:1 | ||||
| 5. Jornada | 04.02.2022 | Atlético San Luis [] | - | Santos Laguna [] | 0:2 | ||||
| 6. Jornada | 12.02.2022 | Santos Laguna [] | - | Atlas Guadalajara [] | 4:3 | ||||
| 7. Jornada | 18.02.2022 | Club León [] | - | Santos Laguna [] | 2:2 | ||||
| 8. Jornada | 26.02.2022 | Mazatlán FC [] | - | Santos Laguna [] | 0:3 | ||||
| 11. Jornada | 19.03.2022 | Santos Laguna [] | - | Atlético San Luis [] | 2:2 | ||||
| 12. Jornada | 26.03.2022 | Santos Laguna [] | - | Mazatlán FC [] | 3:2 | ||||
| 13. Jornada | 03.04.2022 | CF Monterrey [] | - | Santos Laguna [] | 2:0 | ||||
| 18. Jornada | 07.05.2022 | Santos Laguna [] | - | Club León [] | 2:3 |
México