| 26. Jornada | 06.02.2022 | Club Brugge KV | - | Gante | 1:2 |  |
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| 27. Jornada | 13.02.2022 | Club Brugge KV | - | Sporting Charleroi | 2:0 | ||||
| 28. Jornada | 20.02.2022 | KAS Eupen | - | Club Brugge KV | 1:3 | ||||
| 29. Jornada | 27.02.2022 | Club Brugge KV | - | Royal Antwerp FC | 4:1 |  |
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| 30. Jornada | 05.03.2022 | RFC Seraing | - | Club Brugge KV | 0:5 | |
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| 31. Jornada | 12.03.2022 | KV Oostende | - | Club Brugge KV | 1:3 | |
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| 32. Jornada | 20.03.2022 | Club Brugge KV | - | KRC Genk | 3:1 | ||||
| 34. Jornada | 10.04.2022 | Club Brugge KV | - | KV Mechelen | 2:0 | |
Bélgica