| 1. Jornada | 23.07.2021 | FK Rostov | - | Dinamo Moskva | 0:2 |  |
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| 2. Jornada | 01.08.2021 | FK Rostov | - | Zenit | 2:4 | ||||
| 3. Jornada | 08.08.2021 | FK Khimki | - | FK Rostov | 1:1 | ||||
| 4. Jornada | 14.08.2021 | FK Rostov | - | CSKA Moscú | 1:3 | ||||
| 5. Jornada | 22.08.2021 | FK Nizhny Novgorod | - | FK Rostov | 1:2 | |
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| 7. Jornada | 13.09.2021 | FK Rostov | - | FK Krasnodar | 1:1 | ||||
| 8. Jornada | 18.09.2021 | Krylia Sovetov | - | FK Rostov | 4:2 | ||||
| 9. Jornada | 26.09.2021 | FK Rostov | - | Akhmat Grozny | 1:2 | ||||
| 11. Jornada | 16.10.2021 | FK Sochi | - | FK Rostov | 3:2 | ||||
| 15. Jornada | 21.11.2021 | FK Rostov | - | FK Ufa | 2:2 | |
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