| 1. Jornada | 08.01.2022 | Gallos Blancos [] | - | CF América [] | 0:4 |  |
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| 2. Jornada | 26.01.2022 | CF América [] | - | Pumas UNAM [] | 1:2 | ||||
| 4. Jornada | 29.01.2022 | CF Pachuca [] | - | CF América [] | 3:0 | ||||
| 3. Jornada | 09.02.2022 | CF América [] | - | Puebla FC [] | 1:0 | ||||
| 6. Jornada | 12.02.2022 | FC Juárez [] | - | CF América [] | 1:0 | ||||
| 7. Jornada | 19.02.2022 | CF América [] | - | Club Necaxa [] | 3:3 | ||||
| 8. Jornada | 26.02.2022 | CF América [] | - | Deportivo Toluca [] | 1:2 | ||||
| 9. Jornada | 05.03.2022 | Cruz Azul [] | - | CF América [] | 3:1 |  |
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| 11. Jornada | 19.03.2022 | Pumas UNAM [] | - | CF América [] | 1:1 | ||||
| 13. Jornada | 03.04.2022 | Club Necaxa [] | - | CF América [] | 1:2 | ||||
| 15. Jornada | 04.05.2022 | Deportivo Toluca [] | - | CF América [] | 0:2 | ||||
| 18. Jornada | 07.05.2022 | CF América [] | - | FC Juárez [] | 3:0 |
México