| 2. Jornada | 20.03.2022 | Charlotte FC | - | New England Revolution | 3:1 | ||||
| 2. Jornada | 26.03.2022 | Charlotte FC | - | FC Cincinnati | 2:0 | ||||
| 3. Jornada | 24.04.2022 | Colorado Rapids | - | Charlotte FC | 0:0 | ||||
| 5. Jornada | 11.06.2022 | Charlotte FC | - | New York RB | 2:0 |  |
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| 5. Jornada | 26.06.2022 | CF Montréal | - | Charlotte FC | 2:1 | ||||
| 7. Jornada | 04.08.2022 | Charlotte FC | - | D.C. United | 3:0 | ||||
| 7. Jornada | 07.08.2022 | Charlotte FC | - | Chicago Fire | 2:3 |  |
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| 7. Jornada | 18.08.2022 | New York City FC | - | Charlotte FC | 1:3 | ||||
| 7. Jornada | 22.08.2022 | Charlotte FC | - | Orlando City | 1:2 | |
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| 7. Jornada | 28.08.2022 | Charlotte FC | - | Toronto FC | 0:2 | ||||
| 8. Jornada | 04.09.2022 | FC Cincinnati | - | Charlotte FC | 2:0 | ||||
| 8. Jornada | 10.09.2022 | Charlotte FC | - | New York City FC | 1:0 | ||||
| 8. Jornada | 18.09.2022 | Chicago Fire | - | Charlotte FC | 2:3 | |
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| 9. Jornada | 01.10.2022 | Charlotte FC | - | Philadelphia Union | 4:0 | ||||
| 9. Jornada | 06.10.2022 | Charlotte FC | - | Columbus Crew | 2:2 | ||||
| 9. Jornada | 09.10.2022 | New York RB | - | Charlotte FC | 2:0 |
Ghana