| 1. Jornada | 18.02.2021 | Real España | - | Olimpia | 1:2 | ||||
| 3. Jornada | 25.02.2021 | Real España | - | Honduras Progreso | 1:0 | ||||
| 4. Jornada | 27.02.2021 | Marathón | - | Real España | 1:2 | ||||
| 5. Jornada | 05.03.2021 | Real España | - | Vida | 0:0 |  |
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| 6. Jornada | 08.03.2021 | Olimpia | - | Real España | 1:0 | ||||
| 7. Jornada | 12.03.2021 | Real España | - | Platense | 4:0 | ||||
| 8. Jornada | 18.03.2021 | Honduras Progreso | - | Real España | 1:1 | ||||
| 9. Jornada | 21.03.2021 | Real España | - | Marathón | 2:2 | ||||
| 10. Jornada | 04.04.2021 | Vida | - | Real España | 2:3 | ||||
| 12. Jornada | 18.04.2021 | Motagua | - | Real España | 1:0 | ||||
| 14. Jornada | 28.04.2021 | Real España | - | Real Sociedad | 0:0 |
Honduras