| 2. Jornada | 12.08.2021 | Olimpia | - | Real España | 1:1 |  |
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| 3. Jornada | 16.08.2021 | Platense | - | Real España | 0:2 | ||||
| 4. Jornada | 22.08.2021 | Real España | - | Real Sociedad | 1:1 | ||||
| 5. Jornada | 26.08.2021 | Real España | - | Lobos UPNFM | 5:3 | ||||
| 6. Jornada | 29.08.2021 | Marathón | - | Real España | 0:1 | ||||
| 7. Jornada | 05.09.2021 | Vida | - | Real España | 1:0 | ||||
| 8. Jornada | 12.09.2021 | Real España | - | Motagua | 2:1 | ||||
| 9. Jornada | 16.09.2021 | Honduras Progreso | - | Real España | 1:1 | |
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| 10. Jornada | 20.09.2021 | Real España | - | Marathón | 0:1 | ||||
| 11. Jornada | 26.09.2021 | Real Sociedad | - | Real España | 0:4 | ||||
| 12. Jornada | 03.10.2021 | Real España | - | Olimpia | 1:1 | ||||
| 13. Jornada | 10.10.2021 | Victoria | - | Real España | 0:2 | ||||
| 14. Jornada | 17.10.2021 | Real España | - | Platense | 2:1 | ||||
| 15. Jornada | 25.10.2021 | Lobos UPNFM | - | Real España | 1:2 | ||||
| 16. Jornada | 28.10.2021 | Real España | - | Honduras Progreso | 4:1 | |
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| 17. Jornada | 31.10.2021 | Motagua | - | Real España | 0:1 | ||||
| 18. Jornada | 10.11.2021 | Real España | - | Vida | 2:1 |
Honduras