| 1. Jornada | 01.08.2022 | Real España | - | Lobos UPNFM | 1:0 | ||||
| 2. Jornada | 08.08.2022 | Real España | - | Motagua | 1:1 | ||||
| 3. Jornada | 10.08.2022 | Real Sociedad | - | Real España | 2:1 |  |
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| 4. Jornada | 15.08.2022 | Real España | - | Victoria | 2:1 | ||||
| 5. Jornada | 22.08.2022 | Olimpia | - | Real España | 1:1 | |
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| 6. Jornada | 29.08.2022 | Real España | - | Marathón | 2:0 | ||||
| 7. Jornada | 01.09.2022 | Vida | - | Real España | 1:0 | |
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| 9. Jornada | 12.09.2022 | Real España | - | Honduras Progreso | 2:0 | ||||
| 10. Jornada | 19.09.2022 | Lobos UPNFM | - | Real España | 2:2 | ||||
| 11. Jornada | 02.10.2022 | Motagua | - | Real España | 1:2 | ||||
| 12. Jornada | 08.10.2022 | Real España | - | Real Sociedad | 1:3 | |
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| 14. Jornada | 20.10.2022 | Real España | - | Olimpia | 0:0 | ||||
| 15. Jornada | 23.10.2022 | Marathón | - | Real España | 2:0 | |
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| 16. Jornada | 06.11.2022 | Real España | - | Vida | 2:1 | ||||
| 17. Jornada | 13.11.2022 | Real España | - | Olancho FC | 4:3 | |
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| 18. Jornada | 19.11.2022 | Honduras Progreso | - | Real España | 0:0 |
Honduras