| 1. Jornada | 09.01.2021 | Puebla FC | - | Deportivo Guadalajara | 1:1 |  |
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| 2. Jornada | 17.01.2021 | Cruz Azul | - | Puebla FC | 0:1 | ||||
| 4. Jornada | 03.02.2021 | Puebla FC | - | CF Monterrey | 0:0 | ||||
| 6. Jornada | 13.02.2021 | Puebla FC | - | FC Juárez | 4:0 | ||||
| 9. Jornada | 03.03.2021 | Club León | - | Puebla FC | 1:2 | ||||
| 10. Jornada | 06.03.2021 | Puebla FC | - | UANL Tigres | 1:1 | ||||
| 17. Jornada | 03.05.2021 | Santos Laguna | - | Puebla FC | 0:0 | |
México