| 1. Jornada | 16.07.2022 | Sportivo Ameliano | - | Libertad | 2:0 | ||||
| 2. Jornada | 20.07.2022 | Libertad | - | Club Olimpia | 4:2 | ||||
| 3. Jornada | 24.07.2022 | General Caballero DJLM | - | Libertad | 3:2 | ||||
| 4. Jornada | 31.07.2022 | Libertad | - | Resistencia SC | 4:0 |  |
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| 5. Jornada | 06.08.2022 | 12 de Octubre de Itauguá | - | Libertad | 1:3 | |
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| 6. Jornada | 13.08.2022 | Libertad | - | Sol de América | 4:1 | ||||
| 7. Jornada | 21.08.2022 | Club Nacional | - | Libertad | 0:2 | ||||
| 8. Jornada | 27.08.2022 | Libertad | - | Guaraní | 2:2 | ||||
| 9. Jornada | 05.09.2022 | Cerro Porteño | - | Libertad | 1:0 | ||||
| 10. Jornada | 10.09.2022 | Guaireña FC | - | Libertad | 4:0 | ||||
| 11. Jornada | 14.09.2022 | Libertad | - | Tacuary | 2:0 | ||||
| 12. Jornada | 18.09.2022 | Libertad | - | Sportivo Ameliano | 2:1 | ||||
| 17. Jornada | 18.10.2022 | Sol de América | - | Libertad | 1:1 | ||||
| 18. Jornada | 24.10.2022 | Libertad | - | Club Nacional | 0:1 |  |
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| 19. Jornada | 27.10.2022 | Guaraní | - | Libertad | 1:2 | ||||
| 20. Jornada | 01.11.2022 | Libertad | - | Cerro Porteño | 0:0 | ||||
| 22. Jornada | 12.11.2022 | Tacuary | - | Libertad | 1:0 |
Paraguay