| 5. Jornada | 30.01.2022 | Club Celaya | - | CF Monterrey II | 2:1 |  |
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| 6. Jornada | 02.02.2022 | Pumas Tabasco | - | Club Celaya | 0:1 | |
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| 8. Jornada | 16.02.2022 | Coyotes de Tlaxcala | - | Club Celaya | 0:1 | ||||
| 10. Jornada | 02.03.2022 | Alebrijes de Oaxaca | - | Club Celaya | 1:0 | ||||
| 11. Jornada | 09.03.2022 | Club Celaya | - | Atlético Morelia | 2:2 | ||||
| 13. Jornada | 23.03.2022 | Dorados de Sinaloa | - | Club Celaya | 0:2 |  |
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| 14. Jornada | 26.03.2022 | Club Celaya | - | Tapatío | 5:0 | ||||
| 15. Jornada | 31.03.2022 | Club Celaya | - | Mineros de Zacatecas | 2:1 | ||||
| 16. Jornada | 07.04.2022 | TM Fútbol Club | - | Club Celaya | 2:2 | ||||
| 17. Jornada | 14.04.2022 | Club Celaya | - | Venados FC | 1:0 |
Paraguay