| 7. Jornada | 06.09.2021 | Tigres FC | - | Real Santander | 2:0 | ||||
| 8. Jornada | 11.09.2021 | Real Santander | - | Barranquilla FC | 1:1 |  |
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| 9. Jornada | 18.09.2021 | Bogotá FC | - | Real Santander | 1:1 | ||||
| 10. Jornada | 24.09.2021 | Real Santander | - | Atlético FC | 0:2 | ||||
| 11. Jornada | 02.10.2021 | Orsomarso SC | - | Real Santander | 3:1 | ||||
| 12. Jornada | 09.10.2021 | Real Santander | - | Valledupar FC | 1:1 | ||||
| 13. Jornada | 20.10.2021 | Boyacá Chicó | - | Real Santander | 3:1 | ||||
| 14. Jornada | 24.10.2021 | Real Santander | - | Fortaleza FC | 1:1 |
Colombia