| 1. Jornada | 28.07.2021 | Venados FC | - | Club Celaya | 1:2 |  |
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| 2. Jornada | 04.08.2021 | Club Celaya | - | TM Fútbol Club | 0:0 | ||||
| 3. Jornada | 11.08.2021 | Atlético Morelia | - | Club Celaya | 2:1 | ||||
| 4. Jornada | 18.08.2021 | Club Celaya | - | Coyotes de Tlaxcala | 3:0 | |
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| 5. Jornada | 26.08.2021 | CF Monterrey II | - | Club Celaya | 1:0 | ||||
| 6. Jornada | 02.09.2021 | Club Celaya | - | Pumas Tabasco | 1:2 | ||||
| 7. Jornada | 10.09.2021 | Tepatitlán | - | Club Celaya | 0:1 | ||||
| 8. Jornada | 19.09.2021 | Atlante | - | Club Celaya | 1:1 | ||||
| 10. Jornada | 29.09.2021 | Correcaminos UAT | - | Club Celaya | 1:0 | ||||
| 11. Jornada | 07.10.2021 | Club Celaya | - | Cimarrones de Sonora | 1:0 | ||||
| 12. Jornada | 15.10.2021 | Leones Negros | - | Club Celaya | 1:2 | |
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| 13. Jornada | 21.10.2021 | Club Celaya | - | Alebrijes de Oaxaca | 1:0 | ||||
| 14. Jornada | 27.10.2021 | Mineros de Zacatecas | - | Club Celaya | 3:1 | ||||
| 15. Jornada | 03.11.2021 | Club Celaya | - | Dorados de Sinaloa | 2:2 | |
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| 16. Jornada | 12.11.2021 | Tapatío | - | Club Celaya | 1:1 |
México