| 1. Jornada | 07.01.2022 | Club Celaya | - | Tepatitlán | 1:1 | ||||
| 2. Jornada | 12.01.2022 | Cancún FC | - | Club Celaya | 2:0 | ||||
| 3. Jornada | 20.01.2022 | Club Celaya | - | Atlante | 1:1 | ||||
| 5. Jornada | 30.01.2022 | Club Celaya | - | CF Monterrey II | 2:1 |  |
|||
| 6. Jornada | 02.02.2022 | Pumas Tabasco | - | Club Celaya | 0:1 | |
|||
| 7. Jornada | 10.02.2022 | Club Celaya | - | Leones Negros | 0:0 | ||||
| 8. Jornada | 16.02.2022 | Coyotes de Tlaxcala | - | Club Celaya | 0:1 | ||||
| 9. Jornada | 23.02.2022 | Club Celaya | - | Correcaminos UAT | 1:1 | |
|||
| 10. Jornada | 02.03.2022 | Alebrijes de Oaxaca | - | Club Celaya | 1:0 | ||||
| 11. Jornada | 09.03.2022 | Club Celaya | - | Atlético Morelia | 2:2 | |
|||
| 12. Jornada | 17.03.2022 | Cimarrones de Sonora | - | Club Celaya | 3:2 | ||||
| 13. Jornada | 23.03.2022 | Dorados de Sinaloa | - | Club Celaya | 0:2 | ||||
| 14. Jornada | 26.03.2022 | Club Celaya | - | Tapatío | 5:0 | |
|||
| 15. Jornada | 31.03.2022 | Club Celaya | - | Mineros de Zacatecas | 2:1 | ||||
| 16. Jornada | 07.04.2022 | TM Fútbol Club | - | Club Celaya | 2:2 | ||||
| 17. Jornada | 14.04.2022 | Club Celaya | - | Venados FC | 1:0 |
México