| Cuartos de final | 18.11.2021 | Club León [Sub 20] | - | Santos Laguna [Sub 20] | 1:0 | ||||
| Cuartos de final | 21.11.2021 | Santos Laguna [Sub 20] | - | Club León [Sub 20] | 1:0 |  |
|||
| Semifinales | 25.11.2021 | Atlas Guadalajara [Sub 20] | - | Santos Laguna [Sub 20] | 0:1 |  |
|||
| Final | 02.12.2021 | Cruz Azul [Sub 20] | - | Santos Laguna [Sub 20] | 2:1 | ||||
| Final | 05.12.2021 | Santos Laguna [Sub 20] | - | Cruz Azul [Sub 20] | 3:0 |
México