| 1. Jornada | 02.07.2022 | Deportivo Guadalajara [Sub 18] | - | FC Juárez [Sub 18] | 1:0 |  |
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| 3. Jornada | 05.07.2022 | Santos Laguna [Sub 18] | - | Deportivo Guadalajara [Sub 18] | 3:1 | ||||
| 5. Jornada | 27.07.2022 | Gallos Blancos [Sub 18] | - | Deportivo Guadalajara [Sub 18] | 0:1 | ||||
| 6. Jornada | 30.07.2022 | Deportivo Guadalajara [Sub 18] | - | CF Pachuca [Sub 18] | 0:1 | |
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| 7. Jornada | 05.08.2022 | Mazatlán FC [Sub 18] | - | Deportivo Guadalajara [Sub 18] | 2:2 | ||||
| 10. Jornada | 09.08.2022 | Club Necaxa [Sub 18] | - | Deportivo Guadalajara [Sub 18] | 1:2 | ||||
| 8. Jornada | 13.08.2022 | Deportivo Guadalajara [Sub 18] | - | Atlas Guadalajara [Sub 18] | 0:1 | ||||
| 11. Jornada | 27.08.2022 | Deportivo Guadalajara [Sub 18] | - | Pumas UNAM [Sub 18] | 1:0 | |
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| 12. Jornada | 04.09.2022 | Deportivo Toluca [Sub 18] | - | Deportivo Guadalajara [Sub 18] | 1:0 |
México