| 3. Jornada | 22.01.2022 | Deportivo Guadalajara [] | - | Club León [] | 4:0 | ||||
| 7. Jornada | 19.02.2022 | Deportivo Guadalajara [] | - | Mazatlán FC [] | 2:0 | ||||
| 8. Jornada | 26.02.2022 | UANL Tigres [] | - | Deportivo Guadalajara [] | 1:3 | ||||
| 9. Jornada | 05.03.2022 | Deportivo Guadalajara [] | - | Atlas Guadalajara [] | 2:2 | ||||
| 12. Jornada | 26.03.2022 | Club León [] | - | Deportivo Guadalajara [] | 1:4 | ||||
| 15. Jornada | 30.03.2022 | Deportivo Guadalajara [] | - | CF Monterrey [] | 4:1 | ||||
| 16. Jornada | 23.04.2022 | Atlas Guadalajara [] | - | Deportivo Guadalajara [] | 2:1 | ||||
| 18. Jornada | 07.05.2022 | Deportivo Guadalajara [] | - | UANL Tigres [] | 2:1 |
México