| 1. Jornada | 30.07.2000 | Estudiantes | - | River Plate | 1:1 | ||||
| 2. Jornada | 06.08.2000 | River Plate | - | Vélez Sarsfield | 2:1 |  |
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| 3. Jornada | 19.08.2000 | Colón de Santa Fe | - | River Plate | 1:2 | ||||
| 4. Jornada | 27.08.2000 | River Plate | - | Rosario Central | 4:1 |  |
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| 5. Jornada | 06.09.2000 | Independiente | - | River Plate | 0:1 | ||||
| 6. Jornada | 10.09.2000 | River Plate | - | Talleres de Córdoba | 4:1 | ||||
| 7. Jornada | 17.09.2000 | CA Los Andes | - | River Plate | 0:4 | ||||
| 8. Jornada | 24.09.2000 | River Plate | - | San Lorenzo | 2:2 | ||||
| 9. Jornada | 01.10.2000 | Chacarita Juniors | - | River Plate | 1:0 | |
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| 10. Jornada | 15.10.2000 | River Plate | - | Boca Juniors | 1:1 | ||||
| 11. Jornada | 22.10.2000 | Argentinos Juniors | - | River Plate | 2:2 | |
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| 12. Jornada | 27.10.2000 | River Plate | - | Unión de Santa Fe | 1:1 | ||||
| 14. Jornada | 11.11.2000 | River Plate | - | Newell's Old Boys | 2:0 | ||||
| 15. Jornada | 19.11.2000 | Racing Club | - | River Plate | 0:1 | ||||
| 16. Jornada | 26.11.2000 | River Plate | - | Belgrano | 4:2 | ||||
| 17. Jornada | 03.12.2000 | Almagro | - | River Plate | 4:5 | ||||
| 18. Jornada | 10.12.2000 | River Plate | - | Huracán | 1:1 | ||||
| 19. Jornada | 17.12.2000 | CA Lanús | - | River Plate | 3:2 |
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