| 1. Jornada | 12.09.2021 | Boston River | - | Montevideo Wanderers | 1:3 | ||||
| 2. Jornada | 20.09.2021 | Deportivo Maldonado | - | Montevideo Wanderers | 1:3 | ||||
| 3. Jornada | 26.09.2021 | Montevideo Wanderers | - | Rentistas | 2:1 | ||||
| 4. Jornada | 04.10.2021 | Peñarol | - | Montevideo Wanderers | 3:0 | ||||
| 5. Jornada | 09.10.2021 | Montevideo Wanderers | - | Montevideo City Torque | 0:1 | ||||
| 6. Jornada | 17.10.2021 | Villa Española | - | Montevideo Wanderers | 2:2 | ||||
| 12. Jornada | 15.11.2021 | Progreso | - | Montevideo Wanderers | 3:1 |  |
 |
||
| 13. Jornada | 19.11.2021 | Montevideo Wanderers | - | Sud América | 4:1 | ||||
| 14. Jornada | 26.11.2021 | Plaza Colonia | - | Montevideo Wanderers | 0:1 | ||||
| 15. Jornada | 04.12.2021 | Montevideo Wanderers | - | Fénix | 1:1 | |
Uruguay