| 1. Jornada | 25.08.2012 | Defensor Sporting | - | Nacional | 2:2 | ||||
| 2. Jornada | 01.09.2012 | Montevideo Wanderers | - | Defensor Sporting | 0:4 |  |
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| 3. Jornada | 15.09.2012 | Defensor Sporting | - | Liverpool | 2:0 | ||||
| 4. Jornada | 23.09.2012 | Progreso | - | Defensor Sporting | 1:4 |  |
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| 6. Jornada | 07.10.2012 | El Tanque Sisley | - | Defensor Sporting | 1:1 | |
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| 7. Jornada | 14.10.2012 | Defensor Sporting | - | Racing | 1:0 | ||||
| 8. Jornada | 21.10.2012 | Defensor Sporting | - | Danubio | 3:1 | ||||
| 9. Jornada | 28.10.2012 | Central Español | - | Defensor Sporting | 1:1 | |
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| 10. Jornada | 04.11.2012 | Peñarol | - | Defensor Sporting | 2:1 | ||||
| 11. Jornada | 10.11.2012 | Fénix | - | Defensor Sporting | 1:3 | ||||
| 12. Jornada | 17.11.2012 | Defensor Sporting | - | Bella Vista | 4:0 | |
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| 13. Jornada | 24.11.2012 | River Plate | - | Defensor Sporting | 1:1 | ||||
| 14. Jornada | 01.12.2012 | Defensor Sporting | - | Cerro Largo | 1:0 | ||||
| 15. Jornada | 08.12.2012 | Defensor Sporting | - | CA Cerro | 2:0 | |
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