| 1. Jornada | 14.08.2021 | Mosta FC | - | Birkirkara FC | 0:3 |  |
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| 2. Jornada | 21.08.2021 | Birkirkara FC | - | Hamrun Spartans | 2:1 | ||||
| 3. Jornada | 12.09.2021 | Balzan FC | - | Birkirkara FC | 1:2 | ||||
| 9. Jornada | 21.11.2021 | St. Luċija FC | - | Birkirkara FC | 2:0 | ||||
| 10. Jornada | 27.11.2021 | Birkirkara FC | - | Sliema Wanderers | 2:0 | ||||
| 11. Jornada | 04.12.2021 | Valletta FC | - | Birkirkara FC | 0:0 | |
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| 12. Jornada | 12.12.2021 | Birkirkara FC | - | Mosta FC | 2:2 | ||||
| 14. Jornada | 19.01.2022 | Birkirkara FC | - | Balzan FC | 3:2 |  |
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| 15. Jornada | 23.01.2022 | Floriana FC | - | Birkirkara FC | 1:0 | |
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| 13. Jornada | 26.01.2022 | Hamrun Spartans | - | Birkirkara FC | 0:0 | ||||
| 16. Jornada | 30.01.2022 | Birkirkara FC | - | Gżira United | 1:0 | ||||
| 17. Jornada | 06.02.2022 | Gudja United | - | Birkirkara FC | 0:1 | |
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| 18. Jornada | 13.02.2022 | Birkirkara FC | - | Sirens FC | 1:1 | ||||
| 19. Jornada | 19.02.2022 | Hibernians FC | - | Birkirkara FC | 2:3 | |
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| 21. Jornada | 06.03.2022 | Sliema Wanderers | - | Birkirkara FC | 0:0 | ||||
| 22. Jornada | 12.03.2022 | Birkirkara FC | - | Valletta FC | 1:1 | |
Brasil