| 1. Jornada | 16.07.2022 | Sportivo Ameliano | - | Libertad | 2:0 | ||||
| 2. Jornada | 20.07.2022 | Libertad | - | Club Olimpia | 4:2 | ||||
| 3. Jornada | 24.07.2022 | General Caballero DJLM | - | Libertad | 3:2 | ||||
| 7. Jornada | 21.08.2022 | Club Nacional | - | Libertad | 0:2 | ||||
| 8. Jornada | 27.08.2022 | Libertad | - | Guaraní | 2:2 | ||||
| 16. Jornada | 10.10.2022 | Libertad | - | 12 de Octubre de Itauguá | 2:2 | ||||
| 13. Jornada | 13.10.2022 | Club Olimpia | - | Libertad | 1:0 | ||||
| 17. Jornada | 18.10.2022 | Sol de América | - | Libertad | 1:1 | ||||
| 18. Jornada | 24.10.2022 | Libertad | - | Club Nacional | 0:1 | ||||
| 20. Jornada | 01.11.2022 | Libertad | - | Cerro Porteño | 0:0 | ||||
| 21. Jornada | 06.11.2022 | Libertad | - | Guaireña FC | 4:2 |  |
|||
| 22. Jornada | 12.11.2022 | Tacuary | - | Libertad | 1:0 |
Paraguay