| 6. Jornada | 08.07.2021 | Rampla Juniors | - | Albion | 0:1 | ||||
| 7. Jornada | 15.07.2021 | Albion | - | Atenas | 1:0 | ||||
| 8. Jornada | 22.07.2021 | Danubio | - | Albion | 0:2 |  |
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| 9. Jornada | 29.07.2021 | Albion | - | Racing | 0:0 | ||||
| 10. Jornada | 04.08.2021 | Rocha | - | Albion | 0:2 | ||||
| 11. Jornada | 14.08.2021 | Albion | - | Villa Teresa | 2:0 | ||||
| 13. Jornada | 22.09.2021 | Albion | - | Juventud de Las Piedras | 1:0 | ||||
| 14. Jornada | 30.09.2021 | Defensor Sporting | - | Albion | 0:1 | ||||
| 15. Jornada | 04.10.2021 | Albion | - | Uruguay Montevideo | 1:0 | |
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| 16. Jornada | 12.10.2021 | Central Español | - | Albion | 3:4 | |
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| 19. Jornada | 01.11.2021 | Albion | - | Danubio | 2:1 | |
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| 20. Jornada | 09.11.2021 | Racing | - | Albion | 1:1 | ||||
| 21. Jornada | 18.11.2021 | Albion | - | Rocha | 0:1 | ||||
| 22. Jornada | 24.11.2021 | Villa Teresa | - | Albion | 1:1 | |
Uruguay