| 1. Jornada | 07.01.2022 | Puebla FC [Sub 20] | - | CF América [Sub 20] | 1:5 | ||||
| 2. Jornada | 15.01.2022 | UANL Tigres [Sub 20] | - | Puebla FC [Sub 20] | 4:1 | ||||
| 4. Jornada | 06.02.2022 | Gallos Blancos [Sub 20] | - | Puebla FC [Sub 20] | 0:2 |  |
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| 7. Jornada | 26.02.2022 | Deportivo Guadalajara [Sub 20] | - | Puebla FC [Sub 20] | 2:0 | ||||
| 8. Jornada | 01.03.2022 | Puebla FC [Sub 20] | - | FC Juárez [Sub 20] | 2:2 | ||||
| 9. Jornada | 05.03.2022 | Cruz Azul [Sub 20] | - | Puebla FC [Sub 20] | 3:0 | ||||
| 10. Jornada | 13.03.2022 | Atlético San Luis [Sub 20] | - | Puebla FC [Sub 20] | 3:1 | |
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| 11. Jornada | 18.03.2022 | Puebla FC [Sub 20] | - | Santos Laguna [Sub 20] | 0:1 | ||||
| 12. Jornada | 03.04.2022 | Deportivo Toluca [Sub 20] | - | Puebla FC [Sub 20] | 2:0 |
México