| 6. Jornada | 17.10.2021 | AEL Limassol | - | Anorthosis Famagusta | 2:1 | ||||
| 7. Jornada | 25.10.2021 | Anorthosis Famagusta | - | AEK Larnaca | 1:2 | ||||
| 8. Jornada | 29.10.2021 | Omonia Nikosia | - | Anorthosis Famagusta | 0:1 | ||||
| 9. Jornada | 07.11.2021 | Anorthosis Famagusta | - | Paphos FC | 1:0 | ||||
| 11. Jornada | 29.11.2021 | Anorthosis Famagusta | - | Apollon Limassol | 1:1 | ||||
| 12. Jornada | 04.12.2021 | Anorthosis Famagusta | - | PAEEK | 2:3 | ||||
| 13. Jornada | 13.12.2021 | Anorthosis Famagusta | - | Doxa Katokopias | 2:0 | ||||
| 14. Jornada | 18.12.2021 | Ethnikos Achna | - | Anorthosis Famagusta | 0:2 | ||||
| 1. Jornada | 22.12.2021 | PAEEK | - | Anorthosis Famagusta | 0:2 | ||||
| 17. Jornada | 16.01.2022 | Anorthosis Famagusta | - | AEL Limassol | 2:1 | ||||
| 18. Jornada | 24.01.2022 | AEK Larnaca | - | Anorthosis Famagusta | 1:1 |  |
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| 15. Jornada | 10.02.2022 | Anorthosis Famagusta | - | Aris Limassol | 3:1 |  |
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| 21. Jornada | 14.02.2022 | Anorthosis Famagusta | - | Olympiacos Nikosia | 3:1 | ||||
| 16. Jornada | 17.02.2022 | APOEL Nikosia | - | Anorthosis Famagusta | 0:2 | ||||
| 22. Jornada | 26.02.2022 | Apollon Limassol | - | Anorthosis Famagusta | 2:2 | |
Chipre