| 2. Jornada | 19.09.2021 | Apollon Smyrnis | - | Volos NFC | 1:3 |  |
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| 3. Jornada | 22.09.2021 | Olympiacos | - | Apollon Smyrnis | 4:1 | ||||
| 4. Jornada | 27.09.2021 | Apollon Smyrnis | - | Ionikos Nikea | 0:0 | |
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| 5. Jornada | 02.10.2021 | Aris Saloniki | - | Apollon Smyrnis | 0:0 | ||||
| 6. Jornada | 16.10.2021 | Apollon Smyrnis | - | Asteras Tripolis | 0:1 | ||||
| 7. Jornada | 23.10.2021 | Apollon Smyrnis | - | PAS Giannina | 1:0 | ||||
| 8. Jornada | 30.10.2021 | PAOK Saloniki | - | Apollon Smyrnis | 4:1 | |
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| 9. Jornada | 06.11.2021 | Apollon Smyrnis | - | AEK Athen | 2:2 | |
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| 10. Jornada | 21.11.2021 | Panetolikos | - | Apollon Smyrnis | 1:0 |  |
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| 12. Jornada | 04.12.2021 | Atromitos | - | Apollon Smyrnis | 4:1 | ||||
| 16. Jornada | 05.01.2022 | Apollon Smyrnis | - | Olympiacos | 0:0 | ||||
| 18. Jornada | 15.01.2022 | Apollon Smyrnis | - | Aris Saloniki | 0:0 | |
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| 21. Jornada | 02.02.2022 | Apollon Smyrnis | - | PAOK Saloniki | 0:2 | ||||
| 23. Jornada | 12.02.2022 | Apollon Smyrnis | - | Panetolikos | 0:0 | |
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| 14. Jornada | 16.02.2022 | Apollon Smyrnis | - | Panathinaikos | 0:3 | |
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| 26. Jornada | 06.03.2022 | OFI Heraklion | - | Apollon Smyrnis | 2:0 |
Grecia