| 1. Jornada | 28.07.2020 | Atlético San Luis | - | FC Juárez | 1:1 |  |
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| 4. Jornada | 13.08.2020 | Club Tijuana | - | Atlético San Luis | 0:2 | ||||
| 5. Jornada | 16.08.2020 | Deportivo Guadalajara | - | Atlético San Luis | 2:1 | ||||
| 7. Jornada | 30.08.2020 | Atlético San Luis | - | CF América | 1:2 | ||||
| 10. Jornada | 13.09.2020 | Pumas UNAM | - | Atlético San Luis | 3:0 | ||||
| 11. Jornada | 21.09.2020 | Atlético San Luis | - | CF Monterrey | 1:2 | ||||
| 14. Jornada | 16.10.2020 | Atlético San Luis | - | Gallos Blancos | 2:1 | ||||
| 15. Jornada | 26.10.2020 | Santos Laguna | - | Atlético San Luis | 2:1 | |
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| 16. Jornada | 30.10.2020 | Atlético San Luis | - | Mazatlán FC | 0:5 |
México