| 1. Jornada | 06.02.2021 | 12 de Octubre de Itauguá | - | River Plate | 2:2 | ||||
| 2. Jornada | 09.02.2021 | River Plate | - | Guaraní | 1:4 | ||||
| 9. Jornada | 22.03.2021 | Club Olimpia | - | River Plate | 5:1 | ||||
| 12. Jornada | 18.04.2021 | River Plate | - | Sol de América | 0:2 | ||||
| 13. Jornada | 27.04.2021 | Sportivo Luqueño | - | River Plate | 2:2 |  |
|||
| 14. Jornada | 04.05.2021 | River Plate | - | Libertad | 1:3 | ||||
| 15. Jornada | 10.05.2021 | Guaireña FC | - | River Plate | 0:0 | ||||
| 16. Jornada | 16.05.2021 | River Plate | - | Cerro Porteño | 1:1 | ||||
| 17. Jornada | 24.05.2021 | Club Nacional | - | River Plate | 0:1 | |
|||
| 18. Jornada | 30.05.2021 | River Plate | - | Club Olimpia | 1:2 |
Paraguay