| 5. Jornada | 15.08.2021 | Houston Dynamo | - | Colorado Rapids | 1:3 | ||||
| 5. Jornada | 29.08.2021 | Sporting Kansas City | - | Colorado Rapids | 1:1 | ||||
| 6. Jornada | 05.09.2021 | San Jose Earthquakes | - | Colorado Rapids | 0:1 |  |
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| 6. Jornada | 11.09.2021 | Colorado Rapids | - | Los Angeles Galaxy | 1:1 | ||||
| 6. Jornada | 16.09.2021 | Portland Timbers | - | Colorado Rapids | 2:2 | ||||
| 6. Jornada | 26.09.2021 | Colorado Rapids | - | Toronto FC | 0:0 | ||||
| 7. Jornada | 17.10.2021 | Real Salt Lake | - | Colorado Rapids | 3:1 | ||||
| 7. Jornada | 21.10.2021 | Colorado Rapids | - | Seattle Sounders | 1:1 | |
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| 7. Jornada | 24.10.2021 | Colorado Rapids | - | Portland Timbers | 2:0 | |
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| 7. Jornada | 28.10.2021 | New England Revolution | - | Colorado Rapids | 1:0 | ||||
| 7. Jornada | 31.10.2021 | Houston Dynamo | - | Colorado Rapids | 0:1 | |
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| 8. Jornada | 08.11.2021 | Colorado Rapids | - | Los Angeles FC | 5:2 | |
Senegal