| 2. Jornada | 31.07.2021 | Real Santander | - | Unión Magdalena | 3:3 | ||||
| 3. Jornada | 08.08.2021 | Boca Juniors de Cali | - | Real Santander | 0:0 | ||||
| 4. Jornada | 14.08.2021 | Real Santander | - | Real Cartagena | 2:2 | ||||
| 5. Jornada | 20.08.2021 | Leones FC | - | Real Santander | 2:1 | ||||
| 6. Jornada | 28.08.2021 | Real Santander | - | Llaneros FC | 3:1 | ||||
| 7. Jornada | 06.09.2021 | Tigres FC | - | Real Santander | 2:0 |  |
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| 13. Jornada | 20.10.2021 | Boyacá Chicó | - | Real Santander | 3:1 |
Colombia