| 4. Jornada | 15.08.2021 | Platense Zacatecoluca | - | Once Municipal | 1:1 | ||||
| 5. Jornada | 22.08.2021 | FAS | - | Platense Zacatecoluca | 0:1 | ||||
| 6. Jornada | 25.08.2021 | Platense Zacatecoluca | - | Isidro Metapán | 2:1 |  |
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| 7. Jornada | 29.08.2021 | Platense Zacatecoluca | - | Atlético Marte | 0:2 | ||||
| 8. Jornada | 12.09.2021 | Platense Zacatecoluca | - | Santa Tecla FC | 1:0 | |
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| 9. Jornada | 16.09.2021 | CD Águila | - | Platense Zacatecoluca | 1:0 | ||||
| 10. Jornada | 19.09.2021 | Platense Zacatecoluca | - | Jocoro FC | 1:1 | ||||
| 11. Jornada | 26.09.2021 | Municipal Limeño | - | Platense Zacatecoluca | 0:1 | ||||
| 12. Jornada | 02.10.2021 | Platense Zacatecoluca | - | AD Chalatenango | 2:1 | ||||
| 14. Jornada | 09.10.2021 | Platense Zacatecoluca | - | Luis Ángel Firpo | 1:3 | |
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| 13. Jornada | 17.10.2021 | Alianza | - | Platense Zacatecoluca | 4:0 | |
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| 15. Jornada | 24.10.2021 | Once Municipal | - | Platense Zacatecoluca | 1:1 | ||||
| 22. Jornada | 27.11.2021 | Platense Zacatecoluca | - | Municipal Limeño | 0:1 |
El Salvador