| 3. Jornada | 20.06.2021 | FC Cincinnati | - | Colorado Rapids | 0:2 |  |
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| 4. Jornada | 04.07.2021 | Houston Dynamo | - | FC Cincinnati | 1:1 | ||||
| 4. Jornada | 10.07.2021 | FC Cincinnati | - | Columbus Crew | 2:2 |  |
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| 4. Jornada | 18.07.2021 | CF Montréal | - | FC Cincinnati | 5:4 | ||||
| 4. Jornada | 22.07.2021 | FC Cincinnati | - | Atlanta United FC | 1:1 | ||||
| 4. Jornada | 25.07.2021 | Nashville SC | - | FC Cincinnati | 3:0 | ||||
| 6. Jornada | 12.09.2021 | FC Cincinnati | - | Toronto FC | 2:0 | ||||
| 6. Jornada | 16.09.2021 | Atlanta United FC | - | FC Cincinnati | 4:0 | |
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| 6. Jornada | 19.09.2021 | FC Cincinnati | - | New York City FC | 1:2 | ||||
| 6. Jornada | 30.09.2021 | Toronto FC | - | FC Cincinnati | 3:2 | |
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| 7. Jornada | 10.10.2021 | FC Cincinnati | - | Philadelphia Union | 1:2 | |
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| 7. Jornada | 21.10.2021 | FC Cincinnati | - | Chicago Fire | 3:4 | ||||
| 7. Jornada | 24.10.2021 | Inter Miami CF | - | FC Cincinnati | 5:1 | ||||
| 7. Jornada | 28.10.2021 | FC Cincinnati | - | Nashville SC | 3:6 |
Estados Unidos
México