| 1. Jornada | 18.04.2021 | D.C. United | - | New York City FC | 2:1 | ||||
| 1. Jornada | 25.04.2021 | New England Revolution | - | D.C. United | 1:0 | ||||
| 2. Jornada | 02.05.2021 | San Jose Earthquakes | - | D.C. United | 4:1 | ||||
| 2. Jornada | 08.05.2021 | Columbus Crew | - | D.C. United | 3:1 | ||||
| 2. Jornada | 14.05.2021 | D.C. United | - | Chicago Fire | 1:0 |  |
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| 2. Jornada | 17.05.2021 | D.C. United | - | Orlando City | 0:1 | ||||
| 2. Jornada | 24.05.2021 | D.C. United | - | Philadelphia Union | 0:1 | ||||
| 5. Jornada | 16.08.2021 | Nashville SC | - | D.C. United | 5:2 | ||||
| 5. Jornada | 19.08.2021 | New England Revolution | - | D.C. United | 3:2 | ||||
| 5. Jornada | 22.08.2021 | D.C. United | - | Atlanta United FC | 1:2 | ||||
| 5. Jornada | 29.08.2021 | D.C. United | - | Philadelphia Union | 3:1 | ||||
| 6. Jornada | 16.09.2021 | D.C. United | - | Chicago Fire | 3:0 | ||||
| 6. Jornada | 18.09.2021 | Atlanta United FC | - | D.C. United | 3:2 | |
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| 6. Jornada | 26.09.2021 | D.C. United | - | FC Cincinnati | 4:2 | ||||
| 6. Jornada | 30.09.2021 | D.C. United | - | Minnesota United FC | 3:1 | ||||
| 7. Jornada | 03.10.2021 | Orlando City | - | D.C. United | 2:1 |
Perú
