| 1. Jornada | 26.07.2021 | CF Monterrey | - | Puebla FC | 1:1 |  |
|||
| 3. Jornada | 07.08.2021 | Mazatlán FC | - | CF Monterrey | 1:1 | ||||
| 5. Jornada | 19.08.2021 | Cruz Azul | - | CF Monterrey | 1:1 | ||||
| 6. Jornada | 22.08.2021 | CF Monterrey | - | Deportivo Guadalajara | 0:0 | ||||
| 7. Jornada | 28.08.2021 | Club Tijuana | - | CF Monterrey | 2:2 | ||||
| 13. Jornada | 17.10.2021 | CF Monterrey | - | Club León | 0:1 | ||||
| 15. Jornada | 24.10.2021 | CF Monterrey | - | Club Necaxa | 0:1 |  |
México