| 1. Jornada | 24.07.2021 | FK Pardubice | - | MFK Karviná | 2:2 | ||||
| 2. Jornada | 31.07.2021 | MFK Karviná | - | FC Hradec Králové | 1:1 | ||||
| 3. Jornada | 07.08.2021 | Sparta Praga | - | MFK Karviná | 2:0 | ||||
| 4. Jornada | 14.08.2021 | MFK Karviná | - | FC Fastav Zlín | 2:3 | ||||
| 5. Jornada | 22.08.2021 | Viktoria Plzeň | - | MFK Karviná | 2:0 |  |
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| 6. Jornada | 29.08.2021 | MFK Karviná | - | Slavia Praga | 3:3 | ||||
| 7. Jornada | 12.09.2021 | FK Jablonec | - | MFK Karviná | 1:0 | ||||
| 8. Jornada | 19.09.2021 | MFK Karviná | - | FK Teplice | 1:1 | ||||
| 9. Jornada | 25.09.2021 | Dynamo České Budějovice | - | MFK Karviná | 3:1 | ||||
| 10. Jornada | 03.10.2021 | MFK Karviná | - | FK Mladá Boleslav | 0:1 | ||||
| 14. Jornada | 07.11.2021 | MFK Karviná | - | 1. FC Slovácko | 2:2 | ||||
| 15. Jornada | 21.11.2021 | MFK Karviná | - | Slovan Liberec | 1:2 | ||||
| 12. Jornada | 24.11.2021 | MFK Karviná | - | Baník Ostrava | 1:2 |  |
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| 16. Jornada | 28.11.2021 | FC Hradec Králové | - | MFK Karviná | 1:0 | ||||
| 13. Jornada | 01.12.2021 | Bohemians Praha 1905 | - | MFK Karviná | 3:0 | ||||
| 17. Jornada | 04.12.2021 | MFK Karviná | - | Sparta Praga | 1:2 | |
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| 18. Jornada | 11.12.2021 | FC Fastav Zlín | - | MFK Karviná | 2:1 |  |
Brasil