| 1. Jornada | 18.07.2021 | Santa Fe | - | Deportivo Cali | 1:2 |  |
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| 3. Jornada | 04.08.2021 | Santa Fe | - | Atlético Nacional | 0:1 |  |
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| 4. Jornada | 08.08.2021 | Millonarios | - | Santa Fe | 0:1 | ||||
| 5. Jornada | 17.08.2021 | Santa Fe | - | La Equidad | 0:2 | ||||
| 7. Jornada | 30.08.2021 | Santa Fe | - | América de Cali | 1:1 | ||||
| 8. Jornada | 05.09.2021 | Independiente Medellín | - | Santa Fe | 0:0 | ||||
| 9. Jornada | 12.09.2021 | Santa Fe | - | Alianza Petrolera | 1:1 |
Colombia