| 9. Jornada | 26.02.2018 | Santos Laguna | - | Cruz Azul | 2:0 | ||||
| 11. Jornada | 12.03.2018 | Santos Laguna | - | CF Monterrey | 3:2 | ||||
| 12. Jornada | 17.03.2018 | Puebla FC | - | Santos Laguna | 0:1 | ||||
| 13. Jornada | 31.03.2018 | Atlas Guadalajara | - | Santos Laguna | 3:2 | ||||
| 14. Jornada | 09.04.2018 | Santos Laguna | - | Gallos Blancos | 3:0 | ||||
| 15. Jornada | 15.04.2018 | CF Pachuca | - | Santos Laguna | 3:1 | ||||
| 16. Jornada | 23.04.2018 | Santos Laguna | - | Pumas UNAM | 1:2 |  |
Colombia