| 1. Jornada | 09.01.2021 | Mazatlán FC | - | Club Necaxa | 3:2 | ||||
| 2. Jornada | 17.01.2021 | Pumas UNAM | - | Mazatlán FC | 3:0 | ||||
| 4. Jornada | 30.01.2021 | Mazatlán FC | - | CF Pachuca | 1:0 | ||||
| 6. Jornada | 13.02.2021 | Mazatlán FC | - | Atlético San Luis | 0:3 |  |
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| 8. Jornada | 27.02.2021 | Mazatlán FC | - | Gallos Blancos | 3:0 | ||||
| 9. Jornada | 04.03.2021 | Cruz Azul | - | Mazatlán FC | 1:0 | ||||
| 10. Jornada | 07.03.2021 | Mazatlán FC | - | Deportivo Guadalajara | 1:1 | ||||
| 16. Jornada | 24.04.2021 | Mazatlán FC | - | Club León | 4:3 |
México