| 1. Jornada | 12.02.2022 | Unión de Santa Fe | - | River Plate | 1:0 |  |
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| 2. Jornada | 17.02.2022 | River Plate | - | Patronato de Paraná | 4:1 | ||||
| 3. Jornada | 21.02.2022 | Newell's Old Boys | - | River Plate | 0:2 | ||||
| 4. Jornada | 27.02.2022 | River Plate | - | Racing Club | 2:2 | |
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| 7. Jornada | 20.03.2022 | River Plate | - | Boca Juniors | 0:1 | ||||
| 9. Jornada | 11.04.2022 | River Plate | - | Argentinos Juniors | 4:2 | ||||
| 11. Jornada | 21.04.2022 | Talleres de Córdoba | - | River Plate | 1:0 | ||||
| 12. Jornada | 25.04.2022 | River Plate | - | Atlético Tucumán | 1:1 | ||||
| 14. Jornada | 09.05.2022 | River Plate | - | Platense | 2:1 |
Argentina