| 1. Jornada | 25.07.2010 | Universitario de Sucre | - | Club San José | 2:2 |  |
|||
| 2. Jornada | 01.08.2010 | Club San José | - | Blooming | 2:0 | ||||
| 3. Jornada | 08.08.2010 | Jorge Wilstermann | - | Club San José | 1:3 | |
|||
| 5. Jornada | 22.08.2010 | CD Guabirá | - | Club San José | 3:1 | ||||
| 9. Jornada | 12.09.2010 | Bolívar | - | Club San José | 0:0 | ||||
| 10. Jornada | 18.09.2010 | Club San José | - | Real Mamoré | 1:0 | ||||
| 11. Jornada | 25.09.2010 | La Paz FC | - | Club San José | 4:3 | ||||
| 12. Jornada | 03.10.2010 | Club San José | - | Universitario de Sucre | 2:1 | |
|||
| 14. Jornada | 10.10.2010 | Club San José | - | Jorge Wilstermann | 2:0 | ||||
| 15. Jornada | 17.10.2010 | The Strongest | - | Club San José | 1:2 | |
|||
| 16. Jornada | 24.10.2010 | Club San José | - | CD Guabirá | 5:1 | ||||
| 13. Jornada | 28.10.2010 | Blooming | - | Club San José | 2:2 | ||||
| 18. Jornada | 31.10.2010 | Club San José | - | Oriente Petrolero | 0:3 | ||||
| 17. Jornada | 04.11.2010 | Real Potosí | - | Club San José | 1:3 | ||||
| 19. Jornada | 07.11.2010 | Club Aurora | - | Club San José | 4:1 | ||||
| 20. Jornada | 14.11.2010 | Club San José | - | Bolívar | 0:1 | ||||
| 21. Jornada | 21.11.2010 | Real Mamoré | - | Club San José | 3:0 | |
Bolivia