| 1. Jornada | 23.01.2022 | Juventus Managua | - | Managua FC | 1:2 |  |
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| 2. Jornada | 05.02.2022 | Juventus Managua | - | Diriangén FC | 0:2 | ||||
| 5. Jornada | 20.02.2022 | Juventus Managua | - | H&H Export Sébaco | 5:1 | |
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| 7. Jornada | 04.03.2022 | Juventus Managua | - | CD Walter Ferretti | 0:1 | |
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| 8. Jornada | 07.03.2022 | ART Municipal Jalapa | - | Juventus Managua | 1:0 | ||||
| 9. Jornada | 11.03.2022 | UNAN Managua | - | Juventus Managua | 1:2 | |
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| 11. Jornada | 20.03.2022 | Diriangén FC | - | Juventus Managua | 2:2 | ||||
| 12. Jornada | 03.04.2022 | Juventus Managua | - | Real Madriz | 1:1 | ||||
| 13. Jornada | 07.04.2022 | Juventus Managua | - | Real Estelí FC | 0:3 | ||||
| 18. Jornada | 02.05.2022 | Juventus Managua | - | UNAN Managua | 1:3 | |
Nicaragua