| 3. Jornada | 11.09.2021 | Floriana FC | - | Valletta FC | 3:0 | ||||
| 4. Jornada | 19.09.2021 | Birkirkara FC | - | Floriana FC | 1:1 | ||||
| 5. Jornada | 25.09.2021 | Floriana FC | - | Hamrun Spartans | 1:2 |  |
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| 6. Jornada | 16.10.2021 | Balzan FC | - | Floriana FC | 1:2 | |
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| 7. Jornada | 23.10.2021 | Mosta FC | - | Floriana FC | 1:1 | ||||
| 8. Jornada | 31.10.2021 | Floriana FC | - | Gżira United | 2:1 | ||||
| 11. Jornada | 05.12.2021 | Hibernians FC | - | Floriana FC | 0:0 | ||||
| 12. Jornada | 11.12.2021 | St. Luċija FC | - | Floriana FC | 1:3 | ||||
| 13. Jornada | 19.12.2021 | Floriana FC | - | Sliema Wanderers | 2:0 | |
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| 14. Jornada | 17.01.2022 | Valletta FC | - | Floriana FC | 0:2 | ||||
| 15. Jornada | 23.01.2022 | Floriana FC | - | Birkirkara FC | 1:0 | ||||
| 16. Jornada | 30.01.2022 | Hamrun Spartans | - | Floriana FC | 2:2 | ||||
| 17. Jornada | 06.02.2022 | Floriana FC | - | Balzan FC | 2:1 | ||||
| 18. Jornada | 12.02.2022 | Floriana FC | - | Mosta FC | 2:0 | ||||
| 19. Jornada | 20.02.2022 | Gżira United | - | Floriana FC | 1:2 | |
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| 21. Jornada | 06.03.2022 | Sirens FC | - | Floriana FC | 0:3 |
Argentina