| 12. Jornada | 16.09.2021 | Uruguay Montevideo | - | Racing | 1:2 | ||||
| 13. Jornada | 21.09.2021 | Villa Teresa | - | Uruguay Montevideo | 0:1 | ||||
| 14. Jornada | 28.09.2021 | Uruguay Montevideo | - | Juventud de Las Piedras | 1:0 | ||||
| 15. Jornada | 04.10.2021 | Albion | - | Uruguay Montevideo | 1:0 | ||||
| 16. Jornada | 13.10.2021 | Rampla Juniors | - | Uruguay Montevideo | 1:1 | ||||
| 18. Jornada | 27.10.2021 | Rocha | - | Uruguay Montevideo | 1:2 | ||||
| 20. Jornada | 10.11.2021 | Defensor Sporting | - | Uruguay Montevideo | 2:0 |
Uruguay