| 1. Jornada | 22.07.2012 | Santos Laguna | - | Club San Luis | 2:1 |  |
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| 2. Jornada | 29.07.2012 | Club San Luis | - | Cruz Azul | 1:2 | ||||
| 3. Jornada | 04.08.2012 | Monarcas Morelia | - | Club San Luis | 3:3 |  |
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| 4. Jornada | 12.08.2012 | Club San Luis | - | CF Monterrey | 1:1 | ||||
| 5. Jornada | 19.08.2012 | Club San Luis | - | Deportivo Guadalajara | 0:1 | ||||
| 7. Jornada | 02.09.2012 | Club San Luis | - | Club León | 0:2 | ||||
| 8. Jornada | 16.09.2012 | Pumas UNAM | - | Club San Luis | 0:1 | ||||
| 9. Jornada | 23.09.2012 | Club San Luis | - | CF Pachuca | 1:0 | ||||
| 10. Jornada | 30.09.2012 | UANL Tigres | - | Club San Luis | 0:0 | ||||
| 11. Jornada | 03.10.2012 | Club San Luis | - | CF América | 1:2 | ||||
| 12. Jornada | 08.10.2012 | Jaguares Chiapas | - | Club San Luis | 4:0 | ||||
| 13. Jornada | 14.10.2012 | Club San Luis | - | Atlante | 2:2 | ||||
| 14. Jornada | 21.10.2012 | Atlas Guadalajara | - | Club San Luis | 2:3 | |
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| 15. Jornada | 28.10.2012 | Club San Luis | - | Gallos Blancos (old) | 0:0 | ||||
| 16. Jornada | 04.11.2012 | Club Tijuana | - | Club San Luis | 0:0 | ||||
| 17. Jornada | 11.11.2012 | Club San Luis | - | Deportivo Toluca | 0:2 |
México