| 1. Jornada | 31.08.2016 | Boston River | - | Defensor Sporting | 1:1 | ||||
| 2. Jornada | 04.09.2016 | Defensor Sporting | - | Juventud de Las Piedras | 0:1 | ||||
| 4. Jornada | 18.09.2016 | River Plate | - | Defensor Sporting | 0:5 |  |
|||
| 5. Jornada | 24.09.2016 | Defensor Sporting | - | CA Cerro | 0:1 | ||||
| 6. Jornada | 02.10.2016 | Defensor Sporting | - | Montevideo Wanderers | 1:1 | ||||
| 8. Jornada | 16.10.2016 | Defensor Sporting | - | Liverpool | 1:3 | ||||
| 10. Jornada | 29.10.2016 | Rampla Juniors | - | Defensor Sporting | 0:1 | ||||
| 11. Jornada | 12.11.2016 | Villa Española | - | Defensor Sporting | 2:2 | ||||
| 12. Jornada | 20.11.2016 | Defensor Sporting | - | Nacional | 3:2 | ||||
| 15. Jornada | 10.12.2016 | Peñarol | - | Defensor Sporting | 0:2 |
Uruguay