| 2. Jornada | 22.08.2021 | FC-Astoria Walldorf [Juvenil] | - | Mainz [Juvenil] | 1:7 |  |
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| 3. Jornada | 11.09.2021 | Mainz [Juvenil] | - | Ingolstadt [Juvenil] | 4:3 | ||||
| 4. Jornada | 19.09.2021 | SpVgg Unterhaching [Juvenil] | - | Mainz [Juvenil] | 2:1 | ||||
| 5. Jornada | 26.09.2021 | Mainz [Juvenil] | - | 1. FC Kaiserslautern [Juvenil] | 7:1 | |
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| 6. Jornada | 02.10.2021 | Stuttgarter Kickers [Juvenil] | - | Mainz [Juvenil] | 2:1 |  |
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| 7. Jornada | 17.10.2021 | Mainz [Juvenil] | - | Darmstadt [Juvenil] | 0:0 | |
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| 8. Jornada | 24.10.2021 | 1. FC Heidenheim 1846 [Juvenil] | - | Mainz [Juvenil] | 0:3 | ||||
| 9. Jornada | 31.10.2021 | Mainz [Juvenil] | - | Kickers Offenbach [Juvenil] | 4:0 | ||||
| 10. Jornada | 20.11.2021 | SC Freiburg [Juvenil] | - | Mainz [Juvenil] | 1:3 | ||||
| 11. Jornada | 28.11.2021 | Mainz [Juvenil] | - | SSV Ulm 1846 [Juvenil] | 3:2 |
Alemania