| 1. Jornada | 07.02.2021 | Sol de América | - | Cerro Porteño | 1:3 |  |
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| 3. Jornada | 16.02.2021 | Libertad | - | Cerro Porteño | 2:1 | ||||
| 6. Jornada | 06.03.2021 | Club Nacional | - | Cerro Porteño | 2:0 | ||||
| 7. Jornada | 10.03.2021 | Cerro Porteño | - | River Plate | 3:0 | ||||
| 9. Jornada | 21.03.2021 | Cerro Porteño | - | Guaraní | 2:1 | ||||
| 10. Jornada | 05.04.2021 | Cerro Porteño | - | Sol de América | 1:0 | ||||
| 11. Jornada | 12.04.2021 | Sportivo Luqueño | - | Cerro Porteño | 3:3 | ||||
| 12. Jornada | 18.04.2021 | Cerro Porteño | - | Libertad | 0:3 | |
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| 13. Jornada | 25.04.2021 | Guaireña FC | - | Cerro Porteño | 0:1 | ||||
| 15. Jornada | 09.05.2021 | Cerro Porteño | - | Club Nacional | 2:2 | ||||
| 18. Jornada | 29.05.2021 | Guaraní | - | Cerro Porteño | 2:0 |
Paraguay