| 1. Jornada | 31.03.2012 | Toronto FC | - | Columbus Crew | 0:1 | ||||
| 2. Jornada | 07.04.2012 | Columbus Crew | - | New York RB | 1:4 | ||||
| 2. Jornada | 14.04.2012 | Philadelphia Union | - | Columbus Crew | 1:0 |  |
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| 3. Jornada | 06.05.2012 | Portland Timbers | - | Columbus Crew | 0:0 | ||||
| 3. Jornada | 13.05.2012 | Columbus Crew | - | FC Dallas | 2:1 | ||||
| 3. Jornada | 20.05.2012 | San Jose Earthquakes | - | Columbus Crew | 1:1 | ||||
| 3. Jornada | 27.05.2012 | Columbus Crew | - | Chicago Fire | 2:1 | ||||
| 4. Jornada | 17.06.2012 | New England Revolution | - | Columbus Crew | 0:0 | ||||
| 5. Jornada | 15.07.2012 | Columbus Crew | - | Sporting Kansas City | 0:2 | ||||
| 5. Jornada | 22.07.2012 | Columbus Crew | - | D.C. United | 1:0 | ||||
| 7. Jornada | 30.09.2012 | Columbus Crew | - | Philadelphia Union | 3:2 | ||||
| 8. Jornada | 28.10.2012 | Columbus Crew | - | Toronto FC | 2:1 |
Estados Unidos